The Cancer Genome Atlas (TCGA) analyzed the molecular information and the clinical data from more than 10,000 tumors across 33 types of cancers. During this month, researchers published 27 papers on their study results that revealed the origin of cancer cells, oncogenic processes and oncogenic pathways. The results revealed that some key somatic alterations and cancer-related signaling pathways are shared across different cancer types. According to the data, the co-occurrence of actionable mutations were identified in many tumor samples, which suggests the potential of combination therapy opportunities. These findings described the new molecular characteristics of subtypes in pan-cancer, which could serve as a basis to develop new treatment strategies.